I lived at 2350 meters for a year in Central America. A couple of days after my arrival I was invited in on a game of pick-up football with the members of a catechism class. Despite being in reasonable condition, about five minutes later I was feeling a kind of pain I had never known before. And 2350 meters isn’t really that high!
Acetazolamide can help acclimatization but it isn’t a Golden Hammer. Being in Royal Marine condition at sea level would certainly speed acclimatization but no more than that. Seems a lot of time and money to spend on an exercise which was bound to fail.
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