As I said there, the issue is not so much regional boundaries (which, IMO, should be rationalized - see both previosus posts) but rather the bilateral nature of US foreign relations. The current structure is specifically designed to address that. Thus the "chain of command" in US foreign relations runs:

President

US Ambassador to Country X

It also runs:

President

SECSTATE

Regional & functional bureaus in suppport of Ambassadors

And, it runs:

President

SECDEF

GCCs (generally) in support of Ambassadors

So, your regional organizational structure is based on, I think, the faulty premise that we do business - primarily - regionally. Any modification to the current structure must start from the position that US foreign relations are, and probaly will remain, primarily bilateral. Until that changes, all schemes for powerful regional organizations of US foreign relations will fail.

Cheers

JohnT